High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases

The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known....

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Published inIn vivo (Athens) Vol. 8; no. 3; p. 439
Main Authors Sakr, W A, Grignon, D J, Crissman, J D, Heilbrun, L K, Cassin, B J, Pontes, J J, Haas, G P
Format Journal Article
LanguageEnglish
Published Greece 01.05.1994
Subjects
Adenocarcinoma - epidemiology
Adenocarcinoma - ethnology
Adenocarcinoma - pathology
Adult
African Continental Ancestry Group
Age Distribution
Aged
Autopsy
Carcinoma in Situ - epidemiology
Carcinoma in Situ - ethnology
Carcinoma in Situ - pathology
European Continental Ancestry Group
Humans
Male
Middle Aged
Prevalence
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - pathology
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Summary:The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known. Two hundred and forty nine entirely processed prostates from men aged 20-69 were thoroughly evaluated for the presence of PIN and carcinoma. The histologic diagnosis of all positive cases was confirmed by two pathologists. Our results are summarized as follows: Seventy seven percent of the prostates with HGPIN harbored adenocarcinoma, whereas the frequency of cancer in prostates without HGPIN was 24%. HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively. The corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.
ISSN:0258-851X