Matrix effects in clinical analysis: commutability of control materials between the Ektachem, Beckman and SMA 12/60 glucose and urea methods

The effects of the protein matrices of selected human and animal based control materials on the Ektachem, Beckman and SMA 12/60 glucose and urea methods have been investigated by means of commutability studies. The commutability of control materials between the Ektachem and SMA 12/60 was greater tha...

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Bibliographic Details
Published inClinica chimica acta Vol. 113; no. 3; pp. 293 - 303
Main Authors Clark, P M, Kricka, L J, Whitehead, T P
Format Journal Article
LanguageEnglish
Published Netherlands 01.07.1981
Subjects
Autoanalysis
Blood Glucose - analysis
Blood Proteins
Freeze Drying
Humans
Quality Control
Urea - blood
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Summary:The effects of the protein matrices of selected human and animal based control materials on the Ektachem, Beckman and SMA 12/60 glucose and urea methods have been investigated by means of commutability studies. The commutability of control materials between the Ektachem and SMA 12/60 was greater than that between the Ektachem and Beckman methods and was similar to that reported for conventional methods. No trends were apparent amongst control sera from different species nor with different total protein levels. Some variation in commutability was found with different batches of Ektachem glucose and urea slides. In addition the effect of lyophilisation of fresh human serum on its analytical behaviour with different experimental batches of Ektachem glucose/urea slides was studied and found to be negligible.
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ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(81)90282-5