Effects of pinaverium bromide on Oddi's sphincter

Twelve to 15 days after cholecystectomy, endocholedochal pressure was measured in ten patients before and one hour after oral administration of 15 mg of pinaverium bromide (six patients) or placebo. The mean endocholedochal pressure was 7.1 +/- 0.25 mmHg before and 3.1 +/- 0.2 mmHg after pinaverium...

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Bibliographic Details
Published inClinical therapeutics Vol. 9; no. 1; p. 119
Main Authors DiSomma, C, Reboa, G, Patrone, M G, Mortola, G P, Sala, G, Ciampini, M
Format Journal Article
LanguageEnglish
Published United States 1986
Subjects
Ampulla of Vater - drug effects
Common Bile Duct - drug effects
Female
Humans
Male
Middle Aged
Morpholines - pharmacology
Muscle, Smooth - drug effects
Parasympatholytics - pharmacology
Pressure
Sphincter of Oddi - drug effects
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Summary:Twelve to 15 days after cholecystectomy, endocholedochal pressure was measured in ten patients before and one hour after oral administration of 15 mg of pinaverium bromide (six patients) or placebo. The mean endocholedochal pressure was 7.1 +/- 0.25 mmHg before and 3.1 +/- 0.2 mmHg after pinaverium (P less than 0.01), and 7.0 +/- 0.2 and 6.8 +/- 1.2 mmHg in the placebo-treated patients. The results suggest that pinaverium bromide has a specific effect on the common bile duct and probably on Oddi's sphincter.
ISSN:0149-2918