Regression of heart muscle hypertrophy after nifedipine therapy: changes in cardiac gene expression

• Published in: Journal of hypertension. Supplement Vol. 3; no. 3; p. S493
• Main Authors: Zähringer, J, Stangl, E, Danninger, B, Aschauer, W, Motz, W, Strauer, B E
• Format: Journal Article
• Language: English
• Published: England 01.12.1985
• Subjects: Animals; Cardiomegaly - drug therapy; Gene Expression - drug effects; Muscle Proteins - biosynthesis; Muscle Proteins - genetics; Myocardium - metabolism; Nifedipine - therapeutic use; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger - biosynthesis; RNA, Messenger - genetics

Changes in cardiac gene expression were studied during development and regression of cardiac hypertrophy in spontaneously hypertensive rats (SHR) in an attempt to determine some of the biochemical factors responsible for alterations in cardiac mass. Chronic nifedipine treatment of SHR (30 mg/kg per...