Regression of heart muscle hypertrophy after nifedipine therapy: changes in cardiac gene expression

Changes in cardiac gene expression were studied during development and regression of cardiac hypertrophy in spontaneously hypertensive rats (SHR) in an attempt to determine some of the biochemical factors responsible for alterations in cardiac mass. Chronic nifedipine treatment of SHR (30 mg/kg per...

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Bibliographic Details
Published inJournal of hypertension. Supplement Vol. 3; no. 3; p. S493
Main Authors Zähringer, J, Stangl, E, Danninger, B, Aschauer, W, Motz, W, Strauer, B E
Format Journal Article
LanguageEnglish
Published England 01.12.1985
Subjects
Animals
Cardiomegaly - drug therapy
Gene Expression - drug effects
Muscle Proteins - biosynthesis
Muscle Proteins - genetics
Myocardium - metabolism
Nifedipine - therapeutic use
Rats
Rats, Inbred SHR
Rats, Inbred WKY
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
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Summary:Changes in cardiac gene expression were studied during development and regression of cardiac hypertrophy in spontaneously hypertensive rats (SHR) in an attempt to determine some of the biochemical factors responsible for alterations in cardiac mass. Chronic nifedipine treatment of SHR (30 mg/kg per day for 20 weeks) led to a marked reduction in arterial blood pressure and to a subsequent regression of cardiac hypertrophy. Cardiac mRNA concentration decreased, whereas cardiac protein concentration remained unchanged. Changes in cardiac gene expression, as reflected by the decrease in cardiac mRNA concentration, were thus identified as a major factor responsible for the regression of cardiac hypertrophy after nifedipine therapy of SHR.
ISSN:0952-1178