The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy

Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nit...

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Published inIranian Journal of Kidney Diseases Vol. 14; no. 2; p. 81
Main Authors Gerardo Yanowsky-Escatell, Francisco, Andrade-Sierra, Jorge, Pazarín-Villaseñor, Leonardo, Santana-Arciniega, Christian, De Jesús Torres-Vázquez, Eduardo, Samuel Chávez-Iñiguez, Jonathan, Ángel Zambrano-Velarde, Miguel, Martín Preciado-Figueroa, Francisco
Format Journal Article Book Review
LanguageEnglish
Published Iran Iranian Society of Nephrology 01.03.2020
Subjects
Antioxidants
Antioxidants - pharmacology
Apoptosis
Biomarkers - metabolism
Cytokines
Cytokines - metabolism
Diabetes
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - prevention & control
Diabetic nephropathy
Dietary Supplements
Extracellular matrix
Glycation End Products, Advanced
Health sciences
Hemodialysis
Hospitals
Humans
Hyperglycemia
Hyperglycemia - metabolism
Hypoxia
Insulin resistance
Kidney - metabolism
Kidney diseases
Kinases
Nephrology
Nitric oxide
Nitric Oxide - metabolism
Nitrogen dioxide
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pathogenesis
Proteins
Reactive Oxygen Species - metabolism
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Summary:Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nitric oxide, inflammatory markers, and cytokines, among others; are involved in the presence of OS on ND. This revision focus on diverse studies in experimental and human models with diabetes and DN that has been demonstrated beneficial effects of different dietary antioxidant as resveratrol, curcumin, selenium, soy, catechins, α-lipoic acid, coenzyme Q10, omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity for antioxidant response. Therefore, this interventions could have a positive clinical impact on DN.
ISSN:1735-8582
1735-8604