Growth of a plasma cell myeloma in lathyritic mice

Growth of a plasma cell myeloma (Adj PC-5) was studied in mice made lathyritic by the administration of beta-amino-proprionitrile (BAPN). The number of bones that had their medually cavities filled with tumor cells was notably decreased compared with tumor-bearing mice not treated with BAPN. Other a...

Full description

Saved in:
Bibliographic Details
Published inArchives of pathology (1960) Vol. 99; no. 10; p. 536
Main Authors Martino, L J, Yeager, V L, Taylor, J J
Format Journal Article
LanguageEnglish
Published United States 01.10.1975
Subjects
Aminopropionitrile
Animals
Bone Neoplasms - pathology
Exostoses - pathology
Female
Femur - pathology
Lathyrism - chemically induced
Lathyrism - pathology
Male
Mice
Mice, Inbred BALB C
Multiple Myeloma - pathology
Neoplasm Transplantation
Neoplasms, Experimental - pathology
Osteoporosis - pathology
Tibia - pathology
Online AccessGet more information

Cover

More Information
Summary:Growth of a plasma cell myeloma (Adj PC-5) was studied in mice made lathyritic by the administration of beta-amino-proprionitrile (BAPN). The number of bones that had their medually cavities filled with tumor cells was notably decreased compared with tumor-bearing mice not treated with BAPN. Other aspects of tumor growth were the same. BAPN caused some retardation of tumor growth in the medullary cavity, but also caused osteoporosis and decreased tensile strength of collagen that allowed expansion of tumor growth outside the bones to proceed as usual. Additionally, the tumor-bearing mice showed some inhibition in their response to BAPN. This agrees with previous work that has shown that the response to BAPN treatment is greatest in animals that otherwise are healthiest.
ISSN:0363-0153