A new morphological classification during follow-up in patients with celiac disease: a three-dimensional observation by scanning electron microscopy

The structure and ultrastructure of the villi of small intestinal mucosa was examined in 237 duodenal or jejunal biopsies taken from children with active celiac disease and during gluten-free diet. All biopsies were processed for light and scanning electron microscopy. Conventional histology showed...

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Bibliographic Details
Published inHistology and histopathology Vol. 11; no. 2; p. 343
Main Authors Magliocca, F M, Bonamico, M, Petrozza, V, Mariani, P, Correr, S, Familiari, G, Carpino, F
Format Journal Article
LanguageEnglish
Published Spain 01.04.1996
Subjects
Adolescent
Biopsy
Celiac Disease - classification
Celiac Disease - diet therapy
Celiac Disease - pathology
Child
Child, Preschool
Female
Humans
Infant
Intestinal Mucosa - ultrastructure
Jejunum - ultrastructure
Male
Microscopy, Electron, Scanning
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Summary:The structure and ultrastructure of the villi of small intestinal mucosa was examined in 237 duodenal or jejunal biopsies taken from children with active celiac disease and during gluten-free diet. All biopsies were processed for light and scanning electron microscopy. Conventional histology showed four different morphological aspects: total and subtotal villous atrophy in patients on unrestricted diet, partial villous atrophy and normal mucosa during gluten-free diet. Scanning electron microscopy demonstrated that in active celiac disease the severity of the intestinal lesions was related to individual vulnerability to gluten. Our results showed that during dietary treatment the process of mucosal healing was constant and strictly time-dependent. Furthermore, the ultrastructural examination has been relevant in evaluating the evolution of the villous regeneration. In this study a classification regarding the healing process of the small intestinal mucosa correlated with the time of start of dietary therapy is proposed.
ISSN:0213-3911