Pyridoxine-responsive PH1: treatment

Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not...

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Bibliographic Details
Published inJournal of nephrology Vol. 11 Suppl 1; p. 49
Main Author Toussaint, C
Format Journal Article
LanguageEnglish
Published Italy 01.03.1998
Subjects
Female
Humans
Hyperoxaluria, Primary - drug therapy
Kidney Failure, Chronic - prevention & control
Male
Pyridoxine - adverse effects
Pyridoxine - therapeutic use
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Summary:Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not to normal level-in the remaining 30%. In a few aneodotical cases pyridoxine administration was reported to improve kidney function in patients with renal failure secondary to hyperoxaluria. It is reminded that megadoses of pyridoxine (0.5 to 6 g daily) may induce severe sensory neuropathy.
ISSN:1121-8428