Effect of acute hemorrhagic shock on pulmonary microvascular fluid filtration and protein permeability in sheep

In an attempt to further delineate the pathophysiology of the shock-lung syndrome, we studied the effect of hemorrhagic shock on the pulmonary microcirculation in the adult sheep with lung lymph flow and lymph protein transport as indices of fluid filtration and vascular permeability to protein. We...

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Bibliographic Details
Published inSurgery Vol. 77; no. 4; p. 512
Main Authors Demling, R H, Selinger, S L, Bland, R D, Staub, N C
Format Journal Article
LanguageEnglish
Published United States 01.04.1975
Subjects
Acute Disease
Animals
Biological Transport, Active
Blood Pressure
Blood Proteins - metabolism
Capillary Permeability
Disease Models, Animal
Lymph
Microcirculation
Proteins - metabolism
Pulmonary Circulation
Pulmonary Edema - physiopathology
Sheep
Shock, Hemorrhagic - physiopathology
Vascular Resistance
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Summary:In an attempt to further delineate the pathophysiology of the shock-lung syndrome, we studied the effect of hemorrhagic shock on the pulmonary microcirculation in the adult sheep with lung lymph flow and lymph protein transport as indices of fluid filtration and vascular permeability to protein. We noted that lymph flow remained at baseline levels during shock, despite significant decreases in pulmonary artery and left atrial pressures. This suggests that microvascular pressure is maintained by an increase in pulmonary venous resistance. We demonstrated that lymph protein transport does not increase during shock, which indicates that a change in pulmonary vascular permeability to protein does not occur.
ISSN:0039-6060