Cell adhesion molecules in cord blood hematopoietic progenitors

We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to vario...

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Published inBone marrow transplantation (Basingstoke) Vol. 22 Suppl 1; pp. S61 - S62
Main Authors Timeus, F, Crescenzio, N, Marranca, D, Dall'Aglio, M, Fazio, L, Di Marco, M, Saracco, P, Ricotti, M, Gabutti, V
Format Journal Article
LanguageEnglish
Published England 01.07.1998
Subjects
ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1
Antigens, CD
Antigens, CD34 - analysis
Antigens, Differentiation - analysis
Bone Marrow Cells - chemistry
Bone Marrow Cells - cytology
Cell Adhesion Molecules - analysis
Fetal Blood - chemistry
Fetal Blood - cytology
Flow Cytometry
Hematopoietic Stem Cells - chemistry
Humans
L-Selectin - analysis
Lymphocyte Function-Associated Antigen-1 - analysis
Membrane Glycoproteins
NAD+ Nucleosidase - analysis
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Summary:We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to various cytokines increased CD62L expression only in the more differentiated CB and BM CD34+/CD38+ cells.
Bibliography:ObjectType-Article-1
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ISSN:0268-3369
1476-5365