Preoperative radiotherapy and chemotherapy in hypervascular, high-grade supratentorial astrocytomas

From a group of ten patients with hypervascular, high-grade, supratentorial astrocytomas, five were treated with pre-operative radiotherapy alone, and five with radiotherapy in combination with cytostatic drugs. The aim was to investigate the timing of intracranial operations in the multimodality th...

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Bibliographic Details
Published inSurgical neurology Vol. 12; no. 2; p. 131
Main Authors Seiler, R W, Zimmermann, A, Bleher, E A, Markwalder, H
Format Journal Article
LanguageEnglish
Published United States 01.08.1979
Subjects
Adult
Aged
Brain Neoplasms - drug therapy
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Brain Neoplasms - therapy
Drug Therapy, Combination
Female
Glioblastoma - drug therapy
Glioblastoma - radiotherapy
Glioblastoma - surgery
Glioblastoma - therapy
Humans
Lomustine - therapeutic use
Male
Middle Aged
Teniposide - therapeutic use
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Summary:From a group of ten patients with hypervascular, high-grade, supratentorial astrocytomas, five were treated with pre-operative radiotherapy alone, and five with radiotherapy in combination with cytostatic drugs. The aim was to investigate the timing of intracranial operations in the multimodality therapy of brain tumors. The tumor size was diminished only in one case, but tumor vascularization was reduced in half of the cases by the pre-operative treatment. Survival was not improved. Surgical treatment still should be the first of the therapeutic measures. Pre-operative radiotherapy may be of value to reduce tumor vascularization in hypervascular, centrally localized tumors.
ISSN:0090-3019