Plasma insulin, carbohydrate, and free fatty acid changes in newly born infants of diabetic and non-diabetic mothers after loading with glucose, fructose, and galactose

Changes in the concentration of blood glucose, fructose and galactose and their disappearance rate, concentration of plasma insulin, free fatty acids, blood lactate and pyruvate after intravenous glucose, fructose and galactose loads (1 g/kg) were studied in 23 infants of insulin treated diabetic mo...

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Bibliographic Details
Published inPhysiologia Bohemoslovaca Vol. 28; no. 2; p. 113
Main Authors Pribylová, H, Sternová, H, Kimlová, I
Format Journal Article
LanguageEnglish
Published Czech Republic 1979
Subjects
Blood Glucose - analysis
Fatty Acids, Nonesterified - blood
Female
Fructose - blood
Fructose - pharmacology
Galactose - pharmacology
Galactosemias
Glucose - pharmacology
Humans
Infant, Newborn
Insulin - blood
Lactates - blood
Monosaccharides - pharmacology
Pregnancy
Pregnancy in Diabetics - blood
Pyruvates - blood
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Summary:Changes in the concentration of blood glucose, fructose and galactose and their disappearance rate, concentration of plasma insulin, free fatty acids, blood lactate and pyruvate after intravenous glucose, fructose and galactose loads (1 g/kg) were studied in 23 infants of insulin treated diabetic mothers (IDM). The control group consisted of 42 infants of healthy mothers (IHM). The disappearance rate of these monosaccharides was higher in IDM that in IHM (P less than 0.01). All monosaccharides enhanced plasma insulin levels, but the plasma insulin concentration varied considerably. The highest insulin response with difference between IDM and IHM occurred after loading with glucose. Fructose was the least effective insulin stimulator which did not increase glucose levels. All monosaccharides decreased free fatty acid levels. Lactate levels and lactate:pyruvate ratio in IHM were increased after fructose loading. The results of this study suggest that galactose is of some physiological importance for maintaining glucose levels and that the islet apparatus of newborns of diabetic mothers is less loaded with galactose than with glucose.
ISSN:0369-9463