Effect of danazol on thyroid function in women

A longitudinal study of thyroid function during danazol treatment was performed in 18 women. Serum concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), tri-iodothyronine (T3), free T4-and free T3 index as well as thyroid hormone binding globulin (TBG) were measured before and during...

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Bibliographic Details
Published inPostgraduate medical journal Vol. 55 Suppl 5; pp. 33 - 36
Main Authors Thorell, J I, Dymling, J F, Rannevik, G
Format Journal Article
LanguageEnglish
Published England 1979
Subjects
Adult
Danazol - therapeutic use
Endometriosis - blood
Endometriosis - drug therapy
Female
Genital Neoplasms, Female - blood
Genital Neoplasms, Female - drug therapy
Humans
Pregnadienes - therapeutic use
Thyroid Hormones - blood
Thyroxine - blood
Thyroxine-Binding Proteins - blood
Triiodothyronine - blood
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Summary:A longitudinal study of thyroid function during danazol treatment was performed in 18 women. Serum concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), tri-iodothyronine (T3), free T4-and free T3 index as well as thyroid hormone binding globulin (TBG) were measured before and during 6 months therapy. Thyroxine binding globulin showed a marked decrease to one third of the pretreatment level. All the hormones showed significant alterations within the normal ranges for this group. T3 and T4 decreased slightly and the free T4 and free T3 index showed an increase. TSH decreased from 2.4 +/- 0.6 to 1.7 +/- 0.3 mIU/l. The observed hormonal changes were most likely induced by the decreased TBG concentrations and were probably without pathological significance. However these changes must be kept in mind when thyroid function tests from patients with danazol are evaluated.
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ISSN:0032-5473