Foamy myocardial transformation of infancy: 'lipid' or 'histiocytoid' myocardiopathy

Two cases of a distinctive infantile myocardiopathy were studied by light and electron microscopy. They represent the 15th and 16th reported examples of this condition, and include the first associated with morphologically classical endocardial fibroelastosis. The condition is characterized by the p...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 102; no. 6; pp. 306 - 311
Main Authors Witzleben, C L, Pinto, M
Format Journal Article
LanguageEnglish
Published United States 01.06.1978
Subjects
Cardiomyopathies - pathology
Child, Preschool
Endocardial Fibroelastosis - pathology
Female
Humans
Infant
Mitochondria, Heart - ultrastructure
Myocardium - pathology
Myocardium - ultrastructure
Terminology as Topic
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Summary:Two cases of a distinctive infantile myocardiopathy were studied by light and electron microscopy. They represent the 15th and 16th reported examples of this condition, and include the first associated with morphologically classical endocardial fibroelastosis. The condition is characterized by the presence of clusters of foamy or granular cells scattered throughout the myocardium. Ultrastructural studies indicate (1) that lipid storage is not a feature of the condition, and (2) that the abnormal fibers are characterized by a reduced number of fibrils and an increased number of mitochondria. It is proposed that the lesion should be called "foamy myocardial transformation of infancy," and it is speculated that the condition is an acquired metabolic disorder, perhaps occurring in patients abnormally predisposed to such an acquisition.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0003-9985