Developmental approaches to organ restoration

This paper discusses the problem of applying the achievements of developmental biology to organ restoration. Experiments on artificially induced transdifferentiation as a prerequisite for organ restoration are reviewed. The advantage of using cells that start differentiation from the dedifferentated...

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Bibliographic Details
Published inMedical biology Vol. 56; no. 6; p. 344
Main Author Lopashov, G V
Format Journal Article
LanguageEnglish
Published Finland 01.12.1978
Subjects
Amphibians
Animals
Cell Count
Cell Differentiation
Cells, Cultured
Epithelial Cells
Epithelium - embryology
Lens, Crystalline - cytology
Lens, Crystalline - embryology
Regeneration
Retina - cytology
Retina - embryology
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Summary:This paper discusses the problem of applying the achievements of developmental biology to organ restoration. Experiments on artificially induced transdifferentiation as a prerequisite for organ restoration are reviewed. The advantage of using cells that start differentiation from the dedifferentated state is that they can participate in the construction of new organs. However, cell transdifferentiation is not sufficient for biomedical purposes, since the problem of construction of typically formed organs--namely, the morphogenesis of groups of differentiating cells--remains to be solved. Data, where a partial approach to typical organ restoration has been achieved are analysed. This serves as a tentative step in the application of developmental-biological approaches to the problem of organ restoration.
ISSN:0302-2137