Central nervous system actions of clonidine in hypertension

Among 42 patients converted from clonidine to another antihypertensive medication, few sympathomimetic side effects were observed if the clonidine dosage had been less than 1.2 mg daily. Among a majority of 14 patients who had been taking larger doses, the previously reported syndrome of sympathetic...

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Bibliographic Details
Published inMayo Clinic proceedings Vol. 52; no. 6; p. 395
Main Authors Hoobler, S W, Kashima, T
Format Journal Article
LanguageEnglish
Published England 01.06.1977
Subjects
Central Nervous System - drug effects
Clonidine - administration & dosage
Clonidine - adverse effects
Clonidine - pharmacology
Humans
Hyperkinesis - chemically induced
Hypertension - drug therapy
Sympathomimetics
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Summary:Among 42 patients converted from clonidine to another antihypertensive medication, few sympathomimetic side effects were observed if the clonidine dosage had been less than 1.2 mg daily. Among a majority of 14 patients who had been taking larger doses, the previously reported syndrome of sympathetic hyperactivity was observed. It is particularly important to follow up patients who discontinue clonidine when this drug has been taken in excess of 1.2 mg daily.
ISSN:0025-6196