Fatal measles (rubeola) pneumonia in adults

Fatal measles (rubeola) pneumonia, confirmed by viral culture and electron microscopy, occurred in a previously healthy 19-year-old man. Autopsy disclosed measles pneumonia but no recognizable disease that would predispose to such an infection. However, the prolonged course of the measles infection...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 102; no. 7; pp. 366 - 371
Main Authors Sobonya, R E, Hiller, F C, Pingleton, W, Watanabe, I
Format Journal Article
LanguageEnglish
Published United States 01.07.1978
Subjects
Adult
Antibodies - analysis
Humans
Immunity, Cellular
Lung - pathology
Male
Measles - complications
Measles - immunology
Measles - pathology
Pneumonia, Viral - etiology
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Pulmonary Alveoli - pathology
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Summary:Fatal measles (rubeola) pneumonia, confirmed by viral culture and electron microscopy, occurred in a previously healthy 19-year-old man. Autopsy disclosed measles pneumonia but no recognizable disease that would predispose to such an infection. However, the prolonged course of the measles infection and very low levels of serum antibodies to measles indicate that an immune deficient state existed. Nearly all other adults dying of measles pneumonia have had impairment of the immune system, typically due to a lymphatic or hematologic malignant neoplasm treated with chemotherapy. An immunodeficient state may be a precondition for death from measles pneumonia in adults. Enlargement of air spaces with fibrosis in the anterior portions of both lungs is suspected to be due to tissue necrosis and high mechanical ventilatory pressures.
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ISSN:0003-9985