HLA-A1, B8, DRw3 in patients with a distinct form of lupus erythematosus

Subacute cutaneous LE was identified by the presence of widespread nonscarring skin lesions with histologic features of LE. The HLA antigens A1,B8,DRw3 were increased in patients with this condition. The frequency of DRw3 in this group was 77% compared to 24% in controls (p less than 0.001). The rel...

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Bibliographic Details
Published inTransplantation proceedings Vol. 11; no. 4; p. 1869
Main Authors Stastny, P, Gilliam, J N
Format Journal Article
LanguageEnglish
Published United States 01.12.1979
Subjects
Gene Frequency
HLA Antigens - immunology
Humans
Lupus Erythematosus, Discoid - immunology
Lupus Erythematosus, Discoid - pathology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
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Summary:Subacute cutaneous LE was identified by the presence of widespread nonscarring skin lesions with histologic features of LE. The HLA antigens A1,B8,DRw3 were increased in patients with this condition. The frequency of DRw3 in this group was 77% compared to 24% in controls (p less than 0.001). The relative risk with HLA-DRw3 for the subacute cutaneous LE group was 10.8 (p less than 0.001). HLA-A1,B8 antigens were not increased in discoid LE or in the systemic LE group. The results illustrate the value of identifying homogeneous groups of patients for finding meaningful HLA associations.
ISSN:0041-1345