Changes in polyamine metabolism of rat liver after administration of D-galactosamine. Favorable effects of putrescine administration on galactosamine-induced hepatic injury

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 77; no. 1; p. 123
• Main Authors: Daikuhara, Y, Tamada, F, Takigawa, M, Takeda, Y, Mori, Y
• Format: Journal Article
• Language: English
• Published: United States 01.07.1979
• Subjects: Adenosylmethionine Decarboxylase - metabolism; Animals; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - etiology; Female; Galactosamine - pharmacology; Liver - drug effects; Liver - metabolism; Liver Regeneration - drug effects; Ornithine Decarboxylase - metabolism; Polyamines - biosynthesis; Putrescine - therapeutic use; Rats; Spermidine - metabolism
• ISSN: 0016-5085
• DOI: 10.1016/S0016-5085(79)80022-0

There are many reports showing a close relation between polyamine metabolism and tissue growth or recovery of damaged tissues, such as regenerating liver. Thus, changes in polyamine metabolism in the livers from rats treated with D-galactosamine, an inducer of experimental hepatitis, were studied. The activity of ornithine decarboxylase started to increase 14 hr after administration of galactosamine and reached 30 times the normal activity at about 25 hr, the time of maximum severity of hepatitis. The content of putrescine increased to about 10 times the control value. After increases in the putrescine content and ornithine decarboxylase activity, the hepatitis started to diminish. Increases in the activity of S-adenosylmethionine decarboxylase and the content of spermidine were observed 33-37 hr after administration of galactosamine. The maximum values of these parameters, which were significantly higher than the control values, were observed after the healing process had started.