Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites

• Published in: Folia microbiologica Vol. 23; no. 4; p. 255
• Main Authors: Blumauerová, M, Stajner, K, Pokorný, V, Hostálek, Z, Vanĕk, Z
• Format: Journal Article
• Language: English
• Published: United States 01.01.1978
• Subjects: Anthraquinones - biosynthesis; Daunorubicin - biosynthesis; Glycosides - biosynthesis; Mutation; Streptomyces - cytology; Streptomyces - genetics; Streptomyces - metabolism

Mutants of Streptomyces coeruleorubidus, blocked in the biosynthesis of anthracycline antibiotics of the daunomycine complex, were isolated from the production strains after treatment with UV light, gamma-radiation, nitrous acid, and after natural selection; according to their different biosynthetic...