Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites

Mutants of Streptomyces coeruleorubidus, blocked in the biosynthesis of anthracycline antibiotics of the daunomycine complex, were isolated from the production strains after treatment with UV light, gamma-radiation, nitrous acid, and after natural selection; according to their different biosynthetic...

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Published inFolia microbiologica Vol. 23; no. 4; p. 255
Main Authors Blumauerová, M, Stajner, K, Pokorný, V, Hostálek, Z, Vanĕk, Z
Format Journal Article
LanguageEnglish
Published United States 01.01.1978
Subjects
Anthraquinones - biosynthesis
Daunorubicin - biosynthesis
Glycosides - biosynthesis
Mutation
Streptomyces - cytology
Streptomyces - genetics
Streptomyces - metabolism
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Summary:Mutants of Streptomyces coeruleorubidus, blocked in the biosynthesis of anthracycline antibiotics of the daunomycine complex, were isolated from the production strains after treatment with UV light, gamma-radiation, nitrous acid, and after natural selection; according to their different biosynthetic activity the mutants were divided into five phenotypic groups. Mutants of two of these groups produced compounds that had not yet been described in Streptomyces coeruleorubidus (aklavinone, 7-deoxyaklavinone, zeta-rhodomycinone and glycosides of epsilon-rhodomycinone). The mutants differed from the parent strains and also mutually in morphological characteristics but no direct correlation between these changes and the biosynthetic activity could be observed in most cases.
ISSN:0015-5632
DOI:10.1007/BF02876678