The effect of ACTH and diazepam on the uptake of tritiated uridine into brain, muscles and liver of infant rats

In 2-day-old rats, ACTH increases the uptake of 3H-uridine in the brain; no such effects were observed in the msucle and liver tissue. Diazepam does not affect the uptake of 3H-uridine into the brain tissue, but decreases the uptake into the muscle tissue. In the brain tissue of infant rats, ACTH do...

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Bibliographic Details
Published inPhysiologia Bohemoslovaca Vol. 25; no. 4; p. 301
Main Authors Jakoubek, B, Hájek, I
Format Journal Article
LanguageEnglish
Published Czech Republic 1976
Subjects
Adrenocorticotropic Hormone - pharmacology
Animals
Brain - drug effects
Brain - metabolism
Diazepam - pharmacology
Liver - drug effects
Liver - metabolism
Macromolecular Substances - metabolism
Muscles - drug effects
Muscles - metabolism
Rats
Tritium
Uridine - metabolism
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Summary:In 2-day-old rats, ACTH increases the uptake of 3H-uridine in the brain; no such effects were observed in the msucle and liver tissue. Diazepam does not affect the uptake of 3H-uridine into the brain tissue, but decreases the uptake into the muscle tissue. In the brain tissue of infant rats, ACTH does not change the distribution of radioactivity of intraperitoneally administered 3H-uridine among U, Urd, UMP, UDP and UTP. Diazepam increases the amount of radioactivity, found at the U spot. In the muscle, both ACTH and Diazepam increases the amount of radioactivities found in the Urd spot. A significant correlation between the radioactivity of UMP+UDP+UTP and the specific activity of RNA was proved only in the brain. The ratio: specific activity of brain RNA/radioactivity of UMP+UDP+UTP was thus used as a tentative indicator of the biosynthesis of brain RNA. Neither ACTH nor diazepam altered this ratio in infant rats.
ISSN:0369-9463