Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties
A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary...
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Published in | Pharmazie Vol. 54; no. 12; pp. 923 - 925 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
ESCHBORN
GOVI-VERLAG GMBH
01.12.1999
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Subjects | |
Online Access | Get more information |
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Summary: | A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors. |
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ISSN: | 0031-7144 |