Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties

A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary...

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Bibliographic Details
Published inPharmazie Vol. 54; no. 12; pp. 923 - 925
Main Authors Pandeya, SN, Ponnilavarasan, Pandey, A, Lakhan, R, Stables, JP
Format Journal Article
LanguageEnglish
Published ESCHBORN GOVI-VERLAG GMBH 01.12.1999
Subjects
Animals
Anticonvulsants - chemical synthesis
Anticonvulsants - pharmacology
Chemical Phenomena
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Chemistry, Physical
Convulsants
Electroshock
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Mice
Pentylenetetrazole
Pharmacology & Pharmacy
Physical Sciences
Postural Balance - drug effects
Science & Technology
Seizures - chemically induced
Seizures - prevention & control
Semicarbazones - chemical synthesis
Semicarbazones - pharmacology
Spectrophotometry, Infrared
Strychnine
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Summary:A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors.
ISSN:0031-7144