The effects of menadione, ethyl biscoumacetate, and sodium salicylate on the metabolism of mucopolysaccharides in the aortic wall and liver of rats

In rats with hyper- and hypovitaminosis the contents were determined of acid mucopolysaccharides (MPS) on the basis of contents of hexuronic acids; the total contents of biopolymers containing hexosamines (acid MPS, glycoproteins), on the basis of contents of hexosamines in the aortic wall and in th...

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Bibliographic Details
Published inCor et vasa (English ed.) Vol. 19; no. 2; p. 151
Main Authors Sharaev, P N, Bogdanov, N G, Nurkaeva, A T
Format Journal Article
LanguageEnglish
Published Czech Republic 1977
Subjects
Animals
Aorta - enzymology
Aorta - metabolism
Ethyl Biscoumacetate - pharmacology
Glycosaminoglycans - metabolism
Hexosamines - metabolism
Hexuronic Acids - metabolism
Liver - enzymology
Liver - metabolism
Male
Rats
Sodium Salicylate - pharmacology
Vitamin K - pharmacology
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Summary:In rats with hyper- and hypovitaminosis the contents were determined of acid mucopolysaccharides (MPS) on the basis of contents of hexuronic acids; the total contents of biopolymers containing hexosamines (acid MPS, glycoproteins), on the basis of contents of hexosamines in the aortic wall and in the liver; and the activity of glutamine-fructose-6-phosphate aminotransferase (GPAT; EC 2.6.1.16) in the liver. Menadione-induced K hypervitaminosis was accompanied by moderate elevations of indicators of MPS metabolism. Protracted administration of ethyl biscoumacetate or sodium salicylate lowered the contents of acid MPS and of biopolymers containing hexosamines in the aortic wall and in the liver. Simultaneously, the GPAT activity in the liver markedly decreased.
ISSN:0010-8650