Involvement of the cholinergic system in the precocious puberty caused by estradiol in immature female rats

Subcutaneous administration of 0.05 mug estradiol benzoate to sexually immature female rats caused precocious ovulation and a decreased acetylcholine content in the hypothalamus and the amygdala. A higher dose of estradiol benzoate, 2 mug/rat, did not stimulate ovulation but did cause a further decr...

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Bibliographic Details
Published inArchives internationales de pharmacodynamie et de thérapie Vol. 241; no. 2; p. 344
Main Authors Modak, A T, Stavinoha, W B, Hagino, N
Format Journal Article
LanguageEnglish
Published Belgium 01.10.1979
Subjects
Acetylcholine - metabolism
Animals
Brain Chemistry - drug effects
Estradiol - pharmacology
Female
Parasympathetic Nervous System - physiology
Rats
Sexual Maturation - drug effects
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Summary:Subcutaneous administration of 0.05 mug estradiol benzoate to sexually immature female rats caused precocious ovulation and a decreased acetylcholine content in the hypothalamus and the amygdala. A higher dose of estradiol benzoate, 2 mug/rat, did not stimulate ovulation but did cause a further decrease in the acetylcholine content in the hypothalamus and the amygdala. The steady state levels of acetylcholine in the hippocampus and the striatum were unchanged with either dose of estradiol. These observations suggest a relationship between the occurrence of ovulation and the decrease in the steady state level of acetylcholine in the hypothalamus and amygdala in sexually immature rats after estradiol treatment.
ISSN:0003-9780