Doxepin or diazepam for anxious and anxious-depressed outpatients?

A six-week double blind comparison of doxepin and diazepam in the treatment of 61 anxious outpatients showed few drug differences. Diazepam treated patients improved significantly more early in the trial, according to a few measures. They also had significantly fewer complaints of drowsiness. By six...

Full description

Saved in:
Bibliographic Details
Published inThe journal of clinical psychiatry Vol. 39; no. 2; p. 135
Main Authors Haskell, D S, Gambill, J D, Gardos, G, McNair, D M, Fisher, S
Format Journal Article
LanguageEnglish
Published United States 01.02.1978
Subjects
Adolescent
Adult
Aged
Ambulatory Care
Anxiety - drug therapy
Body Weight - drug effects
Clinical Trials as Topic
Depression - drug therapy
Diazepam - adverse effects
Diazepam - therapeutic use
Double-Blind Method
Doxepin - adverse effects
Doxepin - therapeutic use
Drug Evaluation
Female
Humans
Male
Middle Aged
Patient Dropouts
Self-Assessment
Time Factors
Online AccessGet more information

Cover

More Information
Summary:A six-week double blind comparison of doxepin and diazepam in the treatment of 61 anxious outpatients showed few drug differences. Diazepam treated patients improved significantly more early in the trial, according to a few measures. They also had significantly fewer complaints of drowsiness. By six weeks, the medicines appeared roughly equal in efficacy. Practically no support was found for the position that doxepin may be more beneficial for anxious-depressive syndromes. In all patients, and also within the anxious-depressive subgroup, there were small mean differences on many criteria favoring doxepin at six weeks, but none reached significance. The doxepin group gained significantly more weight. Possible biasing influences were present requiring that the results be interpreted with particular caution.
ISSN:0160-6689
1555-2101