Autoimmune cytotoxic granulocyte antibodies in health and disease

Optimum serologic reactivity is observed if papain-treated granulocytes are reacted with cytotoxic antibody at low (5 degrees C) rather than warm (22 degrees C) precomplement incubation temperatures. Favorable in vitro conditions have allowed the identification of cytotoxic granulocyte antibodies in...

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Bibliographic Details
Published inTransplantation proceedings Vol. 9; no. 4; p. 1887
Main Authors Drew, S I, Carter, B M, Guidera, D P, Terasaki, P I
Format Journal Article
LanguageEnglish
Published United States 01.12.1977
Subjects
Agranulocytosis - immunology
Asthma - immunology
Autoantibodies
Cold Temperature
Cytotoxicity, Immunologic
Female
Granulocytes - immunology
Humans
Isoantibodies
Leukocytes - immunology
Lupus Erythematosus, Systemic - immunology
Male
Neutropenia - immunology
Papain
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Summary:Optimum serologic reactivity is observed if papain-treated granulocytes are reacted with cytotoxic antibody at low (5 degrees C) rather than warm (22 degrees C) precomplement incubation temperatures. Favorable in vitro conditions have allowed the identification of cytotoxic granulocyte antibodies in approximately 12% of nonimmunized normal males and females. Furthermore, the incidence of granulocytotoxic antisera in a group of alloimmunized patients did not exceed that observed in the normal population. In two cases cited, a normal male and a patient with pathologic neutropenia, cytotoxic antibodies against allogeneic granulocytes were autoreactive against the autologous cells of the serum producer. In the latter subject, an inverse association was demonstrated between the presence of autoantibody and the circulating neutrophil count. The incidence of granulocytotoxins in various diseases has been given and appears raised in systemic lupus erythematosus and asthma.
ISSN:0041-1345