Immunopathologic aspects of the HBsAg carrier state in chimpanzees

The tissue distribution of hepatitis B virus antigens was correlated with the distribution of immunoglobulins and complement and with histopathological changes. Although no circulating antibody was detected, the participation of humoral immune mechanisms in the elimination of HBsAg from the circulat...

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Bibliographic Details
Published inJournal of medical primatology Vol. 8; no. 4; p. 222
Main Authors Krawczynski, K, Prince, A M, Nowoslawski, A
Format Journal Article
LanguageEnglish
Published Denmark 1979
Subjects
Animals
Carrier State - immunology
Carrier State - pathology
Carrier State - veterinary
Female
Hepatitis B - immunology
Hepatitis B - pathology
Hepatitis B - veterinary
Hepatitis B Surface Antigens - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Kidney Glomerulus - immunology
Liver - immunology
Liver - pathology
Lymph Nodes - immunology
Male
Pan troglodytes - immunology
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Summary:The tissue distribution of hepatitis B virus antigens was correlated with the distribution of immunoglobulins and complement and with histopathological changes. Although no circulating antibody was detected, the participation of humoral immune mechanisms in the elimination of HBsAg from the circulation was suggested by presence of HBsAg, immunoglobulins, and C'3 in germinal centers of mesenteric lymph nodes and HBsAg mixed with immunoglobulins in the mesangium of kidney glomeruli. The results support the hypothesis that the immune status of HBV chimpanzee carriers is associated with hyporesponsiveness rather than tolerance.
ISSN:0047-2565
1600-0684
DOI:10.1159/000460202