Dose dependence of PGBX, a polymeric derivative of prostaglandin B1, for normalization of hereditary diabetes of the mouse

A polymeric derivative of prostaglandin B1, PGBX, which reactivates phosphorylation in damaged mitochondria, is shown to normalize the high blood glucose, obesity, and excessive appetite of the hereditary diabetic mouse. The degree of normalization is shown to vary with dosage.

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Bibliographic Details
Published inPhysiological chemistry and physics Vol. 11; no. 1; pp. 3 - 8
Main Authors Polis, B D, Polis, E
Format Journal Article
LanguageEnglish
Published United States 1979
Subjects
Animals
Blood Glucose
Body Weight - drug effects
Diabetes Mellitus - drug therapy
Diabetes Mellitus - genetics
Diabetes Mellitus - physiopathology
Dose-Response Relationship, Drug
Feeding Behavior - drug effects
Mice
Mice, Mutant Strains - genetics
Prostaglandins - therapeutic use
Prostaglandins B - therapeutic use
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Summary:A polymeric derivative of prostaglandin B1, PGBX, which reactivates phosphorylation in damaged mitochondria, is shown to normalize the high blood glucose, obesity, and excessive appetite of the hereditary diabetic mouse. The degree of normalization is shown to vary with dosage.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0031-9325