Comparative mutagenicity of palmotoxin Bo and aflatoxins B1 and M1

The mutagenicity of palmotoxin Bo and of aflatoxin M1 relative to that of aflatoxin B1, the potent mutagen, was studied in five Ames' Tester Strains of Salmonella typhimurium (TA-98, TA-100, TA-1535, TA-1537, TA-1538). Aflatoxins B1 and M1 are both highly mutagenic in a microsome-mediated syste...

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Bibliographic Details
Published inJournal of environmental pathology and toxicology Vol. 2; no. 4; p. 1099
Main Authors Uwaifo, A O, Emerole, G O, Bababunmi, E A, Bassir, O
Format Journal Article
LanguageEnglish
Published United States 01.03.1979
Subjects
Aflatoxins - metabolism
Aflatoxins - toxicity
Animals
Aspergillus flavus - analysis
Hydroxylation
In Vitro Techniques
Microsomes, Liver - metabolism
Mutagens
Mycotoxins - isolation & purification
Mycotoxins - metabolism
Mycotoxins - toxicity
Rats
Salmonella typhimurium - drug effects
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Summary:The mutagenicity of palmotoxin Bo and of aflatoxin M1 relative to that of aflatoxin B1, the potent mutagen, was studied in five Ames' Tester Strains of Salmonella typhimurium (TA-98, TA-100, TA-1535, TA-1537, TA-1538). Aflatoxins B1 and M1 are both highly mutagenic in a microsome-mediated system in TA-100. The prediction of the relative carcinogenicity of aflatoxin M1 to aflatoxin B1 posed by the mutation of TA-100 is probably more authentic than TA-87. The mutagenic potency of palmotoxin Bo is less than that of either aflatoxin B1 or M1.
ISSN:0146-4779