Effect of intramuscular triamcinolone acetonide on the human ovulatory cycle

• Published in: Cutis (New York, N.Y.) Vol. 19; no. 5; p. 633
• Main Authors: Carson, T E, Daane, T A, Lee, P A, Tredway, D R, Wallin, J D
• Format: Journal Article
• Language: English
• Published: United States 01.05.1977
• Subjects: Estradiol - blood; Female; Follicle Stimulating Hormone - blood; Humans; Injections, Intramuscular; Luteinizing Hormone - blood; Menstruation; Ovulation - drug effects; Progesterone - blood; Triamcinolone Acetonide - administration & dosage; Triamcinolone Acetonide - pharmacology; Hemic System; Progestational Hormones; Anovulation; Genitalia; Progesterone > analysis; Hormones > side effects; Estrogens; Gonadotropins; Ovarian Effects; Biology; Research Methodology; Endocrine System; Genitalia, Female; Urogenital System; Ovary; Gonadotropins, Pituitary; Luteinizing Hormone > analysis; Clinical Research; Hematological Effects; Hormones > administraction and dosage; Physiology; Estradiol > analysis; Follicle Stimulating Hormone > analysis
• ISSN: 0011-4162; 2326-6929

The effect of intramuscular triamcinolone acetonide (TCA-A) on pituitary gonadotropins and ovarian hormones was studied in a normally menstruating woman. Serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well estradiol 17-beta (E2) and progesterone (P), were determined daily in a normal "ovulatory" pretreatment cycle. A total of 160 mg of TCA-A was then administered in four injections over two and a half months. Daily serum levels of LH, FHS, E2, and P were again measured during a period beginning thirty days after the last injection of TCA-A. Cyclicity of all these hormones was absent after treatment. Both LH and FSH were suppressed in the first half of the post-treatment period when compared with the pretreatment ovulatory cycle. A potent corticosteroid such as TCA-A is apparently capable of producing anovulatory cycles in humans by disruption of cyclic pituitary gonadotropin secretion.