Leukocytic function in malakoplakia

Leukocytic functions were studied in a patient with malakoplakia that involved the urinary tract and retroperitoneum in whom recalcitrant infections due to Escherichia coli developed. Polymorphonuclear leukocytic functions and monocytic chemotaxis were normal. Killing of E coli and Staphylococcus au...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 102; no. 10; pp. 534 - 537
Main Authors Schreiber, A G, Maderazo, E G
Format Journal Article
LanguageEnglish
Published United States 01.10.1978
Subjects
Adult
Blood Bactericidal Activity
Escherichia coli Infections
Female
Humans
Hydronephrosis - etiology
Leukocytes - physiology
Lysosomes - enzymology
Malacoplakia - blood
Malacoplakia - complications
Malacoplakia - physiopathology
Monocytes - physiology
Nitroblue Tetrazolium
Ureteral Obstruction - etiology
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Summary:Leukocytic functions were studied in a patient with malakoplakia that involved the urinary tract and retroperitoneum in whom recalcitrant infections due to Escherichia coli developed. Polymorphonuclear leukocytic functions and monocytic chemotaxis were normal. Killing of E coli and Staphylococcus aureus by the patient's monocytes was impaired. This defect persisted after the infections were successfully treated and the treatment with antimicrobial agents was discontinued. Stimulated nitro blue tetrazolium reduction by the patient's monocytes was normal, suggesting that the microbicidal defect was not in the oxygen-dependent microbicidal system. Total lysozymal content of patient's monocytes was normal. Thus, the basis for this microbicidal defect is still undefined.
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ISSN:0003-9985