Splenic B-cell lymphoma with villous lymphocytes (SLVL). A lymphocytic lymphoma simulating hairy cell leukemia. A study of 8 cases

Splenic B cell lymphoma with circulating villous lymphocytes (SLVL) is a lymphoproliferative disorder characterized by the presence in the peripheral blood of atypical B-lymphocytes with hairy appearance. Although the clinical features with massive splenomegaly, absence of peripheral lymphadenopathy...

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Published inNouvelle revue francaise d'hematologie Vol. 32; no. 6; p. 409
Main Authors Valensi, F, Durand, V, Bastenaire, B, Flandrin, G
Format Journal Article
LanguageEnglish
Published Germany 1990
Subjects
Aged
Aged, 80 and over
Antibodies, Neoplasm - blood
Antigens, Differentiation, B-Lymphocyte - blood
Antigens, Neoplasm - blood
B-Lymphocytes - ultrastructure
Biomarkers, Tumor
Bone Marrow - pathology
Diagnosis, Differential
Female
Humans
Leukemia, Hairy Cell - diagnosis
Lymphoma, B-Cell - blood
Lymphoma, B-Cell - diagnosis
Lymphoma, B-Cell - pathology
Male
Middle Aged
Neoplastic Stem Cells - ultrastructure
Receptors, Antigen, B-Cell - analysis
Spleen - pathology
Splenic Neoplasms - blood
Splenic Neoplasms - diagnosis
Splenic Neoplasms - pathology
Splenomegaly - diagnosis
Splenomegaly - etiology
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Summary:Splenic B cell lymphoma with circulating villous lymphocytes (SLVL) is a lymphoproliferative disorder characterized by the presence in the peripheral blood of atypical B-lymphocytes with hairy appearance. Although the clinical features with massive splenomegaly, absence of peripheral lymphadenopathy and blood cytopenia may mimic hairy cell leukemia (HCL), precise analysis of the morphologic and immunologic features allow differential diagnosis between these two entities. Bone marrow and spleen histology resemble the pattern in chronic lymphocytic leukemia (CLL). We studied 8 patients with this entity illustrating the difficulty of diagnosis between SLVL and HCL.