Comparison of tumor-associated surface antigens on cells from medulloblastomas and from other neoplasms of the human nervous system

We used a new immunocytoadhesion method to test 15 different tumors of the human nervous system to see whether medulloblastomas share tumor-associated surface antigens (TSA) with other tumors. Antisera against medulloblastoma cells were raised in rabbits. One antiserum was adsorbed extensively with...

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Bibliographic Details
Published inChild's brain Vol. 4; no. 2; p. 83
Main Authors Sato, K, Raimondi, A J, Dray, S, Molinaro, G A
Format Journal Article
LanguageEnglish
Published Switzerland 1978
Subjects
Adolescent
Adult
Animals
Antigens, Neoplasm - analysis
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Cell Differentiation
Cells, Cultured
Child
Child, Preschool
Erythrocytes - immunology
Female
Humans
Lymphocytes - immunology
Male
Medulloblastoma - immunology
Middle Aged
Rabbits
Rosette Formation
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Summary:We used a new immunocytoadhesion method to test 15 different tumors of the human nervous system to see whether medulloblastomas share tumor-associated surface antigens (TSA) with other tumors. Antisera against medulloblastoma cells were raised in rabbits. One antiserum was adsorbed extensively with tonsil and adenoid cells and with cerebral tissues. Freshly isolated cells from 15 different tumors were first sensitized with the adsorbed antiserum and then rosetted with erythrocytes coated with purified antibody to rabbit immunoglobulin. We found that the antimedulloblastoma antiserum detected TSA on the immunizing medulloblastoma cells and on cells from 2 other medulloblastomas, but apparently not on cells from other tumors (astrocytomas, glioblastomas, neurinoma, meningiomas and craniopharyngioma). In addition, the antiserum probably detected the medulloblastoma TSA on some other tumors (oligodendroglioma, ependymoma and malignant glioma of mixed type).
ISSN:0302-2803