A metabolic approach to the evaluation of peripheral vascular disease

Thirty-five patients with occlusive disease of the arteries underwent metabolic studies. The arteriovenous differences of lactate, glucose and oxygen varied with the severity of the ischemic process, as assessed clinically. Lactate release and glucose extraction were significantly different from con...

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Bibliographic Details
Published inSurgery, gynecology & obstetrics Vol. 144; no. 1; p. 51
Main Authors O'Donnel, Jr, T F, Clowes, Jr, G H, Browse, N L, Ryan, N T, Blackburn, G L
Format Journal Article
LanguageEnglish
Published United States 01.01.1977
Subjects
Aged
Arterial Occlusive Diseases - metabolism
Female
Gangrene - metabolism
Glucose - metabolism
Humans
Hydrogen-Ion Concentration
Ischemia - metabolism
Lactates - metabolism
Leg - blood supply
Male
Middle Aged
Muscles - metabolism
Oxygen Consumption
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Summary:Thirty-five patients with occlusive disease of the arteries underwent metabolic studies. The arteriovenous differences of lactate, glucose and oxygen varied with the severity of the ischemic process, as assessed clinically. Lactate release and glucose extraction were significantly different from control values of patients with rest pain or with ischemic gangrene, while values in patients with claudication were comparable with those in the control group. Percutaneous muscle surface pH measurements, which reflect lactate release, decreased directly with diminished perfusion. Metabolic assessment of arterial occlusive disease may prove to be a useful clinical approach.
ISSN:0039-6087