Combination therapy with verapamil and nitrendipine in patients with hypertension

Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group B) received 20 mg nitrendipine daily during the first six weeks. During the second six weeks, all 40 patients were given 10 mg nitrendipine plus 120...

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Bibliographic Details
Published inJournal of human hypertension Vol. 7; no. 3; p. 305
Main Authors Nalbantgil, I, Onder, R, Kiliçcioğlu, B, Türkoğlu, C
Format Journal Article
LanguageEnglish
Published England 01.06.1993
Subjects
Blood Pressure - drug effects
Drug Therapy, Combination
Heart Rate - drug effects
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Nitrendipine - adverse effects
Nitrendipine - therapeutic use
Verapamil - adverse effects
Verapamil - therapeutic use
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Summary:Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group B) received 20 mg nitrendipine daily during the first six weeks. During the second six weeks, all 40 patients were given 10 mg nitrendipine plus 120 mg verapamil. After the combination therapy, group B received verapamil, 240 mg and group A nitrendipine 20 mg for a further period of six weeks. When verapamil and nitrendipine were used alone, BP decreased significantly in each group. However, BP decreased more when the combination therapy was used and increased when the treatment was changed to single drug therapy from the two-drug combination. In addition, side-effects were three to four times fewer during the combination therapy. It is concluded that the combination of two different calcium antagonists in the treatment of hypertension provides a new dimension to therapy.
ISSN:0950-9240