Karyometric marker features in tissue adjacent to invasive cervical carcinomas

A companion study showed the existence of statistically significant changes in the value of karyometric "marker features" in the nuclei of histologically normal-appearing ectocervical epithelium adjacent to carcinomas in situ. In this second part of the study, the results obtained in patie...

Full description

Saved in:
Bibliographic Details
Published inAnalytical and quantitative cytology and histology Vol. 11; no. 4; p. 281
Main Authors Bibbo, M, Montag, A G, Lerma-Puertas, E, Dytch, H E, Leelakusolvong, S, Bartels, P H
Format Journal Article
LanguageEnglish
Published United States 01.08.1989
Subjects
Carcinoma - pathology
Cell Nucleus - pathology
DNA, Neoplasm - analysis
Female
Humans
Karyotyping
Uterine Cervical Neoplasms - pathology
Online AccessGet more information

Cover

More Information
Summary:A companion study showed the existence of statistically significant changes in the value of karyometric "marker features" in the nuclei of histologically normal-appearing ectocervical epithelium adjacent to carcinomas in situ. In this second part of the study, the results obtained in patients with invasive cervical carcinomas were analyzed. Formalin-fixed, paraffin-embedded tissue sections were Feulgen stained and analyzed with a microTICAS video microphotometer. The results, demonstrated for the first time in histologic material, indicate that the marker features are clearly expressed in a majority of nuclei observed in the normal-appearing tissue adjacent to invasive lesions. This effect was statistically significant. The best marker features selected by the discriminant analysis were nuclear roundness, nuclear perimeter length, total optical density and a run length texture measure. These findings may reflect a subtle transformation of the apparently normal cervical epithelium adjacent to an invasive cervical carcinoma.
ISSN:0884-6812