Enhancing effect of passive immunization with mycobacterial antibodies on humoral and cellular immunity in BCG-infected mice

The present paper is an attempt to get insight about the mechanisms involved in the enhancing phenomenon that occurs in bacterial infections. Mice infected with small doses of the BCG strain of M. bovis and treated with a M. tuberculosis H37Rv antiserum investigated at various intervals for their ca...

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Bibliographic Details
Published inAnnales d'immunologie Vol. 129; no. 2-3; p. 255
Main Authors Forget, A, Turcotte, R, Benoit, J C, Borduas, A G
Format Journal Article
LanguageEnglish
Published France 01.02.1978
Subjects
Animals
Antibodies, Bacterial
Antibody Formation
BCG Vaccine
Cattle
Female
Hypersensitivity, Delayed - immunology
Immune Sera
Immunity, Cellular
Immunity, Maternally-Acquired
Mice
Mycobacterium - immunology
Mycobacterium bovis - growth & development
Mycobacterium tuberculosis - immunology
Spleen - immunology
Tuberculosis, Bovine - immunology
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Summary:The present paper is an attempt to get insight about the mechanisms involved in the enhancing phenomenon that occurs in bacterial infections. Mice infected with small doses of the BCG strain of M. bovis and treated with a M. tuberculosis H37Rv antiserum investigated at various intervals for their capacity to synthesize haemagglutinating antimyco-bacterial antibodies and to develop delayed hypersensitivity to PPD. As controls, BCG-infected mice were treated with the antiserum freed from its mycobacterial antibodies. It was found that the passive immunization of BCG-infected mice promotes the growth of bacilli in their spleen and induces a late formation of antimycobacterial antibodies which do not seem to be related to the development of delayed hypersensitivity.
ISSN:0300-4910