Active enhancement of canine liver allografts with polyspecific antigen

Of 34 canine liver allograft recipients, 17 in the control group survived for 6.9 +/- 1.5 days. Six recipients, group 3, were given 780 milligrams per kilogram of body weight polyspecific semisoluble antigen prepared from 20 spleens together with 10 milligrams per kilogram of body weigth prednisolon...

Full description

Saved in:
Bibliographic Details
Published inSurgery, gynecology & obstetrics Vol. 146; no. 5; p. 783
Main Authors Lie, T S, Rao, G S, Ueda, T, Kim, B R, Rommelsheim, K
Format Journal Article
LanguageEnglish
Published United States 01.05.1978
Subjects
Animals
Antibodies - analysis
Cytotoxicity Tests, Immunologic
Dogs
Epitopes
Graft Survival
Liver - immunology
Liver Transplantation
Lymphocyte Culture Test, Mixed
Rosette Formation
Spleen - immunology
Time Factors
Transplantation, Homologous
Online AccessGet more information

Cover

More Information
Summary:Of 34 canine liver allograft recipients, 17 in the control group survived for 6.9 +/- 1.5 days. Six recipients, group 3, were given 780 milligrams per kilogram of body weight polyspecific semisoluble antigen prepared from 20 spleens together with 10 milligrams per kilogram of body weigth prednisolone on days 15, 8 and 1 before transplantation. The mean survival time of this group was 10.1 +/- 2.0 days, p less than 0.01, compared with the control group. Six other recipients, group 4, were similarly treated with antigen from a pool of 70 spleens. Three survived for more than three weeks, and the other three died on days 1, 7 and 8 postoperatively with signs of accelerated rejection. Donors and recipients were not identical for leukocyte defined determinants. The recipients displaying accelerated rejection had markedly higher lymphocytotoxic and hemagglutinating antibodies. In addition, all recipients undergoing progressive rejection showed an inhibition of leukocyte migration. After three antigen dosages, rosette forming lymphocytes were present in increased numbers in peripheral blood and remained unchanged thereafter.
ISSN:0039-6087