Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 34; no. 4; pp. 932 - 943
• Main Authors: Grimm, Simone, Boesiger, Peter, Beck, Johannes, Schuepbach, Daniel, Bermpohl, Felix, Walter, Martin, Ernst, Jutta, Hell, Daniel, Boeker, Heinz, Northoff, Georg
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2009; Nature Publishing Group
• Subjects: Adult; Analysis of Variance; Behavioral Sciences; Biological Psychology; Brain - physiology; Brain Mapping; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Emotions; Female; Humans; Investigations; Judgment - physiology; Magnetic Resonance Imaging; Male; Medical laboratories; Medicine; Medicine & Public Health; Mental depression; Models, Psychological; Neurosciences; original-article; Oxygen - blood; Pharmacotherapy; Psychiatrists; Psychiatry; Reaction Time; Visual Perception - physiology; Switzerland; Germany; negative BOLD responses; default-mode network; major depressive disorder; event-related fMRI; emotional processing

Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate corte...