Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects

Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate corte...

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Published inNeuropsychopharmacology (New York, N.Y.) Vol. 34; no. 4; pp. 932 - 943
Main Authors Grimm, Simone, Boesiger, Peter, Beck, Johannes, Schuepbach, Daniel, Bermpohl, Felix, Walter, Martin, Ernst, Jutta, Hell, Daniel, Boeker, Heinz, Northoff, Georg
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.03.2009
Nature Publishing Group
Subjects
Adult
Analysis of Variance
Behavioral Sciences
Biological Psychology
Brain - physiology
Brain Mapping
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Emotions
Female
Humans
Investigations
Judgment - physiology
Magnetic Resonance Imaging
Male
Medical laboratories
Medicine
Medicine & Public Health
Mental depression
Models, Psychological
Neurosciences
original-article
Oxygen - blood
Pharmacotherapy
Psychiatrists
Psychiatry
Reaction Time
Visual Perception - physiology
Switzerland
Germany
negative BOLD responses
default-mode network
major depressive disorder
event-related fMRI
emotional processing
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Summary:Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional–cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.
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ISSN:0893-133X
1740-634X
1740-634X
DOI:10.1038/npp.2008.81