Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family
The main function of cyclic AMP phosphodiesterases (PDEs) is to degrade cAMP, a ubiquitous second messenger. Therefore, PDEs can function as prime regulators of cAMP/PKA-dependent processes such as steroidogenesis. Until recently, the roles of the PDE8 family have been largely unexplored, presumably...
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Published in | Hormone and metabolic research Vol. 44; no. 10; p. 790 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Germany
01.09.2012
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Subjects | |
Online Access | Get more information |
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Summary: | The main function of cyclic AMP phosphodiesterases (PDEs) is to degrade cAMP, a ubiquitous second messenger. Therefore, PDEs can function as prime regulators of cAMP/PKA-dependent processes such as steroidogenesis. Until recently, the roles of the PDE8 family have been largely unexplored, presumably due to the lack of a selective inhibitor. This review focuses on recent reports about the regulatory roles of the PDE8 family in adrenal steroidogenesis, as well as the inhibitory properties and specificity of a new PDE8-selective inhibitor, PF-04957325. We also describe a method of measuring urinary corticosterone levels in vivo as a minimally invasive way of monitoring the stress level in a mouse. |
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ISSN: | 1439-4286 |
DOI: | 10.1055/s-0032-1321861 |