Obliterative lesions in a heterotopic bronchial xenograft model--a preliminary study

We further developed our heterotopic pig model of obliterative bronchiolitis to study airway obliteration in xenografts. Four domestic piglets each received 40 bronchial xenografts s.c. from a donor lamb. Piglet X was not immunosuppressed. The other animals received daily oral cyclosporine, 15 mg/kg...

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Bibliographic Details
Published inTransplantation Vol. 70; no. 1; p. 48
Main Authors Salminen, U S, Maasilta, P K, Taskinen, E I, Harjula, A L
Format Journal Article
LanguageEnglish
Published United States 15.07.2000
Subjects
Animals
Bronchi - blood supply
Bronchi - pathology
Bronchi - transplantation
Bronchiolitis Obliterans - etiology
Cartilage - pathology
Cyclosporine - pharmacology
Epithelium - pathology
Everolimus
Sheep
Sirolimus - analogs & derivatives
Sirolimus - pharmacology
Skin
Swine
Transplantation, Heterologous
Transplantation, Heterotopic
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Summary:We further developed our heterotopic pig model of obliterative bronchiolitis to study airway obliteration in xenografts. Four domestic piglets each received 40 bronchial xenografts s.c. from a donor lamb. Piglet X was not immunosuppressed. The other animals received daily oral cyclosporine, 15 mg/kg (XC), or SDZ RAD, 1.5 mg/kg (XR), or both (XCR). Five implants at a time were serially removed from each animal during 17 days for histological assessment. In contrast to the grafts of the others, the xenografts of XCR recovered after initial ischemic damage. No epithelial damage (P<0.01) or mural necrosis occurred on day 7. Airway obliteration developed in all, but was significantly delayed in XCR. Invariably developing airway obliteration in nontreated xenografts was delayed by immunosuppression, making the model useful, especially in testing the efficacy of immunosuppressive drugs in a xenogeneic system.
ISSN:0041-1337