Immunization of chimpanzees with recombinant gp160, but not infection with human immunodeficiency virus type 1, induces envelope-specific Th1 memory cells

• Published in: The Journal of infectious diseases Vol. 171; no. 2; pp. 437 - 440
• Main Authors: MANNHALTER, J. W, FISCHER, M. B, WOLF, H. M, KÜPCÜ, Z, BARRETT, N, DORNER, F, EDER, G, EIBL, M. M
• Format: Journal Article
• Language: English
• Published: Chicago, IL University of Chicago Press 01.02.1995
• Subjects: AIDS/HIV; Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Gene Products, env - genetics; Gene Products, env - immunology; HIV Antibodies - biosynthesis; HIV Envelope Protein gp160; HIV Infections - immunology; HIV Infections - prevention & control; HIV-1 - immunology; human immunodeficiency virus 1; Immunization; Immunologic Memory; Leukocytes, Mononuclear - immunology; Lymphokines - biosynthesis; Microbiology; Pan troglodytes; Protein Precursors - genetics; Protein Precursors - immunology; Recombinant Proteins - immunology; Th1 Cells - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Virology; Immunization; Immunostimulation; Immune response; HIV-1 virus; Monkey; Retroviridae; Helper cell; Cellular immunity; Vaccine; Virus; Vertebrata; Mammalia; T-Lymphocyte; Primates; Lentivirinae; Coat protein; Human immunodeficiency virus; Virus envelope
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/171.2.437

The human immunodeficiency virus (HIV) type 1 envelope protein (recombinant [r] gp160)-induced T cell lymphokine release pattern of chimpanzees immunized with HIVIIIB rpg160 tested and compared with rpg160-induced lymphokine releases of T cells from unimmunized, HIV-1-infected chimpanzees. The results showed that infection of chimpanzees with HIV-1 did not induce rgp160-specific memory T cells (as evidenced by the lack of Th1 and 2 type lymphokine releases after rgp160 stimulation). In contrast, T cells of rgp160-immunized chimpanzees released Th1 type lymphokines upon stimulation with rgp160 of HIVIIIB, HIVMN, and HIVRF. release was comparable whether chimpanzees were immunized with rgp160 only or also challenged with HIV-1 and protected or not protected. Thus, rgp160 immunization leads to generation of Th1 type memory cells. Whether Th1 type responses contribute to protection against HIV-1 infection has yet to be clarified.