Restriction fragment length polymorphism of complement C4 in Japanese patients with rheumatoid arthritis and normal Japanese

Restriction fragment length polymorphism (RFLP) of the two genes for complement C4A and C4B was studied in 56 Japanese patients with rheumatoid arthritis (RA) and 161 normal individuals. HindIII digestion revealed six common patterns, from which the segregation of three common RFLP-types were deduce...

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Published inTissue antigens Vol. 35; no. 5; p. 197
Main Authors Mimori, A, Takeuchi, F, Tokunaga, K, Maeda, H, Matsuki, K, Matsuta, K, Nakano, K, Kosuge, E, Yukiyama, Y, Omoto, K
Format Journal Article
LanguageEnglish
Published England 01.05.1990
Subjects
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Chromosome Mapping
Complement C4 - genetics
Complement C4 - immunology
DNA - genetics
Female
HLA-DR4 Antigen - genetics
HLA-DR4 Antigen - immunology
Humans
Male
Oceanic Ancestry Group - genetics
Pedigree
Polymorphism, Restriction Fragment Length
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Summary:Restriction fragment length polymorphism (RFLP) of the two genes for complement C4A and C4B was studied in 56 Japanese patients with rheumatoid arthritis (RA) and 161 normal individuals. HindIII digestion revealed six common patterns, from which the segregation of three common RFLP-types were deduced; 32-15 kb, 32-25 kb, and 32-20-13-6.5 kb. The last type showed positive associations with C4B5 and HLA-DR4. In the RA patients, an increase of this type was found as well as a decrease of the 32-15 kb/32-25-15 kb heterozygotes.
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1990.tb01782.x