Genetic organization of the unc-22 IV gene and the adjacent region in Caenorhabditis elegans

The genetic organization of the region immediately adjacent to the unc-22 IV gene in Caenorhabditis elegans has been studied. We have identified twenty essential genes in this interval of approximately 1.5-map units on Linkage Group IV. The mutations that define these genes were positioned by recomb...

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Bibliographic Details
Published inMolecular & general genetics Vol. 201; no. 3; p. 409
Main Authors Rogalski, T M, Baillie, D L
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Alleles
Animals
Caenorhabditis - genetics
Chromosome Mapping
Genes
Genetic Linkage
Mutation
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Summary:The genetic organization of the region immediately adjacent to the unc-22 IV gene in Caenorhabditis elegans has been studied. We have identified twenty essential genes in this interval of approximately 1.5-map units on Linkage Group IV. The mutations that define these genes were positioned by recombination mapping and complementation with several deficiencies. With few exceptions, the positions obtained by these two methods agreed. Eight of the twenty essential genes identified are represented by more than one allele. Three possible internal deletions of the unc-22 gene have been located by intra-genic mapping. In addition, the right end point of a deficiency or an inversion affecting the adjacent genes let-56 and unc-22 has been positioned inside the unc-22 gene.
ISSN:0026-8925
DOI:10.1007/BF00331331