Different races have different immune microenvironments: comparison of White and Asian patients with liver cancer

Different ethnic groups have different incidence rate of hepatocellular carcinoma (HCC). In addition to lifestyle and environmental factors, genetic susceptibility is also an important reason. In this study, we screened the immune related genes and stromal related genes in White and Asian liver canc...

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Published inAmerican journal of cancer research Vol. 13; no. 3; pp. 1118 - 1127
Main Authors Wen, Gui-Min, Song, Chang-Liang, Liu, Da-Hua, Xia, Pu
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2023
Subjects
Brief Communication
GPM6A
Hepatocellular carcinoma
tumor microenvironment
IL-18RAP
immunotherapy
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Summary:Different ethnic groups have different incidence rate of hepatocellular carcinoma (HCC). In addition to lifestyle and environmental factors, genetic susceptibility is also an important reason. In this study, we screened the immune related genes and stromal related genes in White and Asian liver cancer patients cohort of The Cancer Genome Atlas (TCGA) the using ESTIMATE algorithm. Hub genes that significantly associated with overall survival (OS) were selected from White and Asian liver cancer patients, respectively. In addition, we validated the functions of two hub genes, IL-18RAP and GPM6A, and . We confirmed different races have different tumor immune microenvironments. Immune microenvironment can influence and change the efficacy of immunotherapy for liver cancer patients.
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Equal contributors.
ISSN:2156-6976
2156-6976