Extracellular HMGB1 as a proinflammatory cytokine

High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activate...

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Bibliographic Details
Published inJournal of interferon & cytokine research Vol. 24; no. 6; pp. 329 - 333
Main Authors Chen, Guoqian, Ward, Mary F, Sama, Andrew E, Wang, Haichao
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 01.06.2004
Subjects
Animals
Cytokines - immunology
HMGB1 Protein - immunology
Humans
Inflammation - metabolism
Signal Transduction - physiology
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Summary:High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activated innate immune cells or necrotic cells and functions as an important mediator of endotoxemia, sepsis, arthritis, and local inflammation. Therapeutic agents that inhibit HMGB1 release or action confer significant protection against endotoxemia, sepsis, and arthritis in animal models and thus hold potential for the clinical management of various inflammatory diseases.
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ISSN:1079-9907
1557-7465
DOI:10.1089/107999004323142187