Cellular Senescence in Cardiovascular Diseases: A Systematic Review

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of death around the world. Recently, cellular senescence has received potential attention as a promising target in preventing cardiovascular diseases, including acute myocardial infarction, atherosclerosis, card...

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Published inAging and disease Vol. 13; no. 1; pp. 103 - 128
Main Authors Hu, Can, Zhang, Xin, Teng, Teng, Ma, Zhen-Guo, Tang, Qi-Zhu
Format Journal Article
LanguageEnglish
Published United States JKL International LLC 01.02.2022
Subjects
Review
Cardiomyocytes
Cardiovascular diseases
Cardiac aging
Cellular senescence
Senotherapy
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ISSN2152-5250
2152-5250
DOI10.14336/AD.2021.0927

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Summary:Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of death around the world. Recently, cellular senescence has received potential attention as a promising target in preventing cardiovascular diseases, including acute myocardial infarction, atherosclerosis, cardiac aging, pressure overload-induced hypertrophy, heart regeneration, hypertension, and abdominal aortic aneurysm. Here, we discuss the mechanisms underlying cellular senescence and describe the involvement of senescent cardiovascular cells (including cardiomyocytes, endothelial cells, vascular smooth muscle cells, fibroblasts/myofibroblasts and T cells) in age-related cardiovascular diseases. Then, we highlight the targets (SIRT1 and mTOR) that regulating cellular senescence in cardiovascular disorders. Furthermore, we review the evidence that senescent cells can exert both beneficial and detrimental implications in cardiovascular diseases on a context-dependent manner. Finally, we summarize the emerging pro-senescent or anti-senescent interventions and discuss their therapeutic potential in preventing cardiovascular diseases.
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These authors contributed equally to this work.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2021.0927